Metabolism of polycyclic compounds. 7. The metabolism of naphthalene, 1-naphthol and 1:2-dihydroxy-1:2-dihydronaphthalene by animals

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Metabolism of Polycyclic Compounds. the Metabolism of 1,4-epoxy-1,4-dihydronaphthalene in Rats.

1. 1,4-Epoxy-1,4-dihydronaphthalene is converted by rats into 1,4:2,3-diepoxy-1,2,3,4-tetrahydronaphthalene, which was isolated from the urine. The synthesis of the diepoxide is described. 2. The monoepoxide also yielded a compound that is believed to be 1,4-dihydro-1,4-dihydroxynaphthalene, but no corresponding mercapturic acid was detected. A number of unidentified metabolites of the monoepox...

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The metabolism of naphthalene and 1-naphthol by houseflies and rats.

Stern, I. J., Wang, C. H. & Gilmour, C. M. (1960). J. Bact. 79, 601. Stoppani, A. 0. M., Conches, L., de Favelukes, S. L. & Sacerdote, F. L. (1958). Biochem. J. 70, 438. Tomlinson, N. (1954). J. biol. Chem. 209, 597. Utter, M. F. & Kurahashi, K. (1954). J. biol. Chem. 207, 821. Van Slyke, D. D., MacFayden, D. A. & Hamilton, P. B. (1943). J. biol. Chem. 150, 251. Wang, C. H. & Jones, D. E. (1959...

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The regulation of naphthalene and 1-naphthol metabolism in a Rhodococcus sp. (NCIMB 12038) has been investigated. The microorganism utilizes separate pathways for the degradation of these compounds, and they are regulated independently. Naphthalene metabolism was inducible, but not by salicylate, and 1-naphthol metabolism, although constitutive, was also repressed during growth on salicylate. T...

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Metabolism of Polycyclic Compounds 21. THE METABOLISM OF PHENANTHRENE IN RABBITS AND RATS: DIHYDRO- DIHYDROXY COMPOUNDS AND RELATED GLUCOSIDURONIC ACIDS BY E. BOYLAND AND P. SIMS

It was shown by Young (1947) and by Boyland & Wolf (1950) that rats convert phenanthrene into trans 9,10 dihydro-9,10 dihydroxyphenanthrene; the latter workers further showed that rabbits convert phenanthrene into this compound and also into trans-1,2-dihydro-1,2-dihydroxyphenanthrene. Bergel & Pschorr (1903) had found that phenanthrene causes an increased excretion of glucuronic acid conjugate...

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Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1953

ISSN: 0306-3283

DOI: 10.1042/bj0530636